| August 2025Aug 16 |  Coppa Italia | Cremonese 0–0 Palermo1st Round | D |
| Aug 23 |  Serie B | Palermo2–1 ReggianaRegular Season - 1 | W |
| Aug 30 | Serie B | Palermo0–0 FrosinoneRegular Season - 2 | D |
| September 2025Sep 14 | Serie B | Sudtirol 0–2PalermoRegular Season - 3 | W |
| Sep 19 | Serie B | Palermo2–0 BariRegular Season - 4 | W |
| Sep 23 | Coppa Italia | Udinese 2–1Palermo2nd Round | L |
| Sep 27 | Serie B | Cesena 1–1PalermoRegular Season - 5 | D |
| Sep 30 | Serie B | Palermo0–0 VeneziaRegular Season - 6 | D |
| October 2025Oct 04 | Serie B | Spezia 1–2PalermoRegular Season - 7 | W |
| Oct 19 | Serie B | Palermo1–1 ModenaRegular Season - 8 | D |
| Oct 25 | Serie B | Catanzaro 1–0PalermoRegular Season - 9 | L |
| Oct 28 | Serie B | Palermo0–3 MonzaRegular Season - 10 | L |
| November 2025Nov 01 | Serie B | Palermo5–0 PescaraRegular Season - 11 | W |
| Nov 08 | Serie B | Juve Stabia 1–0PalermoRegular Season - 12 | L |
| Nov 22 | Serie B | Virtus Entella 1–1PalermoRegular Season - 13 | D |
| Nov 29 | Serie B | Palermo5–0 CarrareseRegular Season - 14 | W |
| December 2025Dec 07 | Serie B | Empoli 1–3PalermoRegular Season - 15 | W |
| Dec 12 | Serie B | Palermo1–0 SampdoriaRegular Season - 16 | W |
| Dec 20 | Serie B | Avellino 2–2PalermoRegular Season - 17 | D |
| Dec 27 | Serie B | Palermo1–0 PadovaRegular Season - 18 | W |
| January 2026Jan 11 | Serie B | Mantova 1–1PalermoRegular Season - 19 | D |
| Jan 18 | Serie B | Palermo1–0SpeziaRegular Season - 20 | W |
| Jan 24 | Serie B | Modena0–0PalermoRegular Season - 21 | D |
| Jan 30 | Serie B | Bari0–3PalermoRegular Season - 22 | W |
| February 2026Feb 07 | Serie B | Palermo3–2EmpoliRegular Season - 23 | W |
| Feb 10 | Serie B | Sampdoria3–3PalermoRegular Season - 24 | D |
| Feb 14 | Serie B | Palermo3–0Virtus EntellaRegular Season - 25 | W |
| Feb 21 | Serie B | Palermo3–0SudtirolRegular Season - 26 | W |
| March 2026Mar 01 | Serie B | Pescara2–1PalermoRegular Season - 27 | L |
| Mar 04 | Serie B | Palermo2–1MantovaRegular Season - 28 | W |
| Mar 08 | Serie B | Carrarese0–1PalermoRegular Season - 29 | W |
| Mar 14 | Serie B | Monza3–0PalermoRegular Season - 30 | L |
| Mar 17 | Serie B | Palermo2–2Juve StabiaRegular Season - 31 | D |
| Mar 21 | Serie B | Padova0–1PalermoRegular Season - 32 | W |
| April 2026Apr 05 | Serie B | Palermo2–0AvellinoRegular Season - 33 | W |
| Apr 10 | Serie B | Frosinone1–1PalermoRegular Season - 34 | D |
| Apr 18 | Serie B | Palermo2–0CesenaRegular Season - 35 | W |
| Apr 25 | Serie B | Reggiana1–1PalermoRegular Season - 36 | D |
| May 2026May 01 | Serie B | Palermo3–2CatanzaroRegular Season - 37 | W |
| May 08 | Serie B | Venezia2–0PalermoRegular Season - 38 | L |
| May 17 | Serie B | Catanzaro3–0PalermoSemi-finals | L |
| May 20 | Serie B | Palermo2–0CatanzaroSemi-finals | W |
