| agosto de 202523 ago |  Serie A | Sassuolo 0–2 NapoliRegular Season - 1 | V |
| 30 ago | Serie A | Napoli1–0 CagliariRegular Season - 2 | V |
| septiembre de 202513 sept | Serie A | Fiorentina 1–3NapoliRegular Season - 3 | V |
| 18 sept |  Champions League | Manchester City 2–0NapoliLeague Stage - 1 | D |
| 22 sept | Serie A | Napoli3–2 PisaRegular Season - 4 | V |
| 28 sept | Serie A | AC Milan 2–1NapoliRegular Season - 5 | D |
| octubre de 202501 oct | Champions League | Napoli2–1 Sporting CPLeague Stage - 2 | V |
| 05 oct | Serie A | Napoli2–1 GenoaRegular Season - 6 | V |
| 18 oct | Serie A | Torino 1–0NapoliRegular Season - 7 | D |
| 21 oct | Champions League | PSV Eindhoven 6–2NapoliLeague Stage - 3 | D |
| 25 oct | Serie A | Napoli3–1 InterRegular Season - 8 | V |
| 28 oct | Serie A | Lecce 0–1NapoliRegular Season - 9 | V |
| noviembre de 202501 nov | Serie A | Napoli0–0 ComoRegular Season - 10 | E |
| 04 nov | Champions League | Napoli0–0 Eintracht FrankfurtLeague Stage - 4 | E |
| 09 nov | Serie A | Bologna 2–0NapoliRegular Season - 11 | D |
| 22 nov | Serie A | Napoli3–1 AtalantaRegular Season - 12 | V |
| 25 nov | Champions League | Napoli2–0 QarabagLeague Stage - 5 | V |
| 30 nov | Serie A | AS Roma 0–1NapoliRegular Season - 13 | V |
| diciembre de 202507 dic | Serie A | Napoli2–1 JuventusRegular Season - 14 | V |
| 10 dic | Champions League | Benfica 2–0NapoliLeague Stage - 6 | D |
| 14 dic | Serie A | Udinese 1–0NapoliRegular Season - 15 | D |
| 28 dic | Serie A | Cremonese 0–2NapoliRegular Season - 17 | V |
| enero de 202604 ene | Serie A | Lazio 0–2NapoliRegular Season - 18 | V |
| 07 ene | Serie A | Napoli2–2 Hellas VeronaRegular Season - 19 | E |
| 11 ene | Serie A | Inter2–2NapoliRegular Season - 20 | E |
| 14 ene | Serie A | Napoli0–0 ParmaRegular Season - 16 | E |
| 17 ene | Serie A | Napoli1–0SassuoloRegular Season - 21 | V |
| 20 ene | Champions League | FC Copenhagen 1–1NapoliLeague Stage - 7 | E |
| 25 ene | Serie A | Juventus3–0NapoliRegular Season - 22 | D |
| 28 ene | Champions League | Napoli2–3 ChelseaLeague Stage - 8 | D |
| 31 ene | Serie A | Napoli2–1FiorentinaRegular Season - 23 | V |
| febrero de 202607 feb | Serie A | Genoa2–3NapoliRegular Season - 24 | V |
| 15 feb | Serie A | Napoli2–2AS RomaRegular Season - 25 | E |
| 22 feb | Serie A | Atalanta2–1NapoliRegular Season - 26 | D |
| 28 feb | Serie A | Hellas Verona1–2NapoliRegular Season - 27 | V |
| marzo de 202606 mar | Serie A | Napoli2–1TorinoRegular Season - 28 | V |
| 14 mar | Serie A | Napoli2–1LecceRegular Season - 29 | V |
| 20 mar | Serie A | Cagliari0–1NapoliRegular Season - 30 | V |
| abril de 202606 abr | Serie A | Napoli1–0AC MilanRegular Season - 31 | V |
| 12 abr | Serie A | Parma1–1NapoliRegular Season - 32 | E |
| 18 abr | Serie A | Napoli0–2LazioRegular Season - 33 | D |
| 24 abr | Serie A | Napoli4–0CremoneseRegular Season - 34 | V |
| mayo de 202602 may | Serie A | Como0–0NapoliRegular Season - 35 | E |
| 11 may | Serie A | Napoli2–3BolognaRegular Season - 36 | D |
| 17 may | Serie A | Pisa0–3NapoliRegular Season - 37 | V |
| 24 may | Serie A | Napoli1–0UdineseRegular Season - 38 | V |
