| agosto de 202517 ago |  Ligue 1 | Stade Brestois 29 3–3 LilleRegular Season - 1 | E |
| 24 ago | Ligue 1 | Lille1–0 MonacoRegular Season - 2 | V |
| 30 ago | Ligue 1 | Lorient 1–7LilleRegular Season - 3 | V |
| septiembre de 202514 sept | Ligue 1 | Lille2–1 ToulouseRegular Season - 4 | V |
| 20 sept | Ligue 1 | Lens 3–0LilleRegular Season - 5 | D |
| 25 sept |  Europa League | Lille2–1 BrannLeague Stage - 1 | V |
| 28 sept | Ligue 1 | Lille0–1 LyonRegular Season - 6 | D |
| octubre de 202502 oct | Europa League | AS Roma 0–1LilleLeague Stage - 2 | V |
| 05 oct | Ligue 1 | Lille1–1 Paris Saint GermainRegular Season - 7 | E |
| 19 oct | Ligue 1 | Nantes 0–2LilleRegular Season - 8 | V |
| 23 oct | Europa League | Lille3–4 PAOKLeague Stage - 3 | D |
| 26 oct | Ligue 1 | Lille6–1 MetzRegular Season - 9 | V |
| 29 oct | Ligue 1 | Nice 2–0LilleRegular Season - 10 | D |
| noviembre de 202502 nov | Ligue 1 | Lille1–0 AngersRegular Season - 11 | V |
| 06 nov | Europa League | FK Crvena Zvezda 1–0LilleLeague Stage - 4 | D |
| 09 nov | Ligue 1 | Strasbourg 2–0LilleRegular Season - 12 | D |
| 23 nov | Ligue 1 | Lille4–2 Paris FCRegular Season - 13 | V |
| 27 nov | Europa League | Lille4–0 Dinamo ZagrebLeague Stage - 5 | V |
| 30 nov | Ligue 1 | Le Havre 0–1LilleRegular Season - 14 | V |
| diciembre de 202505 dic | Ligue 1 | Lille1–0 MarseilleRegular Season - 15 | V |
| 11 dic | Europa League | BSC Young Boys 1–0LilleLeague Stage - 6 | D |
| 14 dic | Ligue 1 | Auxerre 3–4LilleRegular Season - 16 | V |
| enero de 202603 ene | Ligue 1 | Lille0–2 RennesRegular Season - 17 | D |
| 16 ene | Ligue 1 | Paris Saint Germain3–0LilleRegular Season - 18 | D |
| 22 ene | Europa League | Celta Vigo 2–1LilleLeague Stage - 7 | D |
| 25 ene | Ligue 1 | Lille1–4StrasbourgRegular Season - 19 | D |
| 29 ene | Europa League | Lille1–0 SC FreiburgLeague Stage - 8 | V |
| febrero de 202601 feb | Ligue 1 | Lyon1–0LilleRegular Season - 20 | D |
| 06 feb | Ligue 1 | Metz0–0LilleRegular Season - 21 | E |
| 14 feb | Ligue 1 | Lille1–1Stade Brestois 29Regular Season - 22 | E |
| 19 feb | Europa League | Lille0–1FK Crvena ZvezdaRound of 32 | D |
| 22 feb | Ligue 1 | Angers0–1LilleRegular Season - 23 | V |
| 26 feb | Europa League | FK Crvena Zvezda0–1LilleRound of 32 | V |
| marzo de 202601 mar | Ligue 1 | Lille1–0NantesRegular Season - 24 | V |
| 08 mar | Ligue 1 | Lille1–1LorientRegular Season - 25 | E |
| 12 mar | Europa League | Lille0–1 Aston VillaRound of 16 | D |
| 15 mar | Ligue 1 | Rennes1–2LilleRegular Season - 26 | V |
| 19 mar | Europa League | Aston Villa2–0LilleRound of 16 | D |
| 22 mar | Ligue 1 | Marseille1–2LilleRegular Season - 27 | V |
| abril de 202604 abr | Ligue 1 | Lille3–0LensRegular Season - 28 | V |
| 12 abr | Ligue 1 | Toulouse0–4LilleRegular Season - 29 | V |
| 18 abr | Ligue 1 | Lille0–0NiceRegular Season - 30 | E |
| 26 abr | Ligue 1 | Paris FC0–1LilleRegular Season - 31 | V |
| mayo de 202603 may | Ligue 1 | Lille1–1Le HavreRegular Season - 32 | E |
| 10 may | Ligue 1 | Monaco0–1LilleRegular Season - 33 | V |
| 17 may | Ligue 1 | Lille0–2AuxerreRegular Season - 34 | D |
